Medullary control of nociceptive transmission: Reciprocal dual communication with the spinal cord

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2006

Autores

Almeida, A (Autor) Outra; Leite Almeida, H (Autor) Outra; Isaura Tavares (Autor) FMUP

Revista

A Revista está pendente de validação pelos Serviços Administrativos.

Título: Drug Discovery Today: Disease Mechanisms

Vol. 3

Páginas: 305-312

ISSN: 1740-6765

Editora: Elsevier B.V.

Indexação

Scopus - 18 Citações

Outras Informações

ID Authenticus: P-007-H1S

DOI: 10.1016/j.ddmec.2006.09.001

Abstract (EN): Control of pain perception, essential for organism surviving and recovery from disease, is exerted by higher brain centers integrating nociception with emotional and cognitive information and modulating the brainstem-spinal feedback loops that regulate spinal nociceptive transmission. Development of chronic pain deregulates the forebrain-brainstem-spinal pain control system, which leads to neuroplasticity and disruption of a balanced brain-spinal communication. Targets for impeding pain chronification are being developed using the manipulation of the cross talk between brain and dorsal horn, at both sites of the loop.

Idioma: Inglês

Tipo (Avaliação Docente): Científica