Nucleus-Cytoskeleton Crosstalk During Mitotic Entry

• Tipo: Artigo em Revista Científica Internacional
• Data: 2021

Autores

Dantas, M (Autor) Outra; Lima, JT (Autor) Outra; J Ferreira (Autor) FMUP

Revista

Título: Frontiers in Cell and Developmental Biology

Vol. 9

Editora: Frontiers Media

Indexação

ISI Web of Knowledge - 1 Citação

Scopus - 2 Citações

Outras Informações

ID Authenticus: P-00T-P01

DOI: 10.3389/fcell.2021.649899

Abstract (EN): In preparation for mitosis, cells undergo extensive reorganization of the cytoskeleton and nucleus, so that chromosomes can be efficiently segregated into two daughter cells. Coordination of these cytoskeletal and nuclear events occurs through biochemical regulatory pathways, orchestrated by Cyclin-CDK activity. However, recent studies provide evidence that physical forces are also involved in the early steps of spindle assembly. Here, we will review how the crosstalk of physical forces and biochemical signals coordinates nuclear and cytoplasmic events during the G2-M transition, to ensure efficient spindle assembly and faithful chromosome segregation.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9