Risk and survival of third primary cancers in a population-based cohort of gastric cancer patients

• Tipo: Artigo em Revista Científica Internacional
• Data: 2019

Autores

Morais, S (Autor) FMUP; Antunes, L (Autor) Outra; Bento, MJ (Autor) Outra; Lunet N (Autor) FMUP

Revista

Título: Digestive and Liver Disease

Vol. 51

Páginas: 584-588

ISSN: 1590-8658

Editora: Elsevier

Indexação

ISI Web of Knowledge - 1 Citação

Scopus - 1 Citação

Outras Informações

ID Authenticus: P-00Q-EHP

DOI: 10.1016/j.dld.2018.12.003

Abstract (EN): Background: The growing number of gastric cancers together with improved survival resulted in an increasing population of survivors at risk of multiple primary cancers. Aims: To estimate the 10-year risk and survival of third primary cancers (TPCs) among gastric first primary cancers (FPCs). Methods: Gastric FPCs from the Portuguese North Region Cancer Registry, diagnosed in 2000-2006 (n = 7409), were followed for a TPC (31/12/2012), and for all-cause death (31/12/2017). The cumulative incidence of TPCs was estimated. Patients with a TPC were matched (1: 1, by sex, age group, years between FPC and second primary cancer [ SPC] diagnosis, and SPC location) to FPC + SPC patients without a TPC. Results: Overall, 25 (0.3% of FPCs and 6.8% of SPCs) TPCs were diagnosed. The most common sites were tobacco-related, mainly including digestive organs. Among all FPCs, 10-year cumulative incidence (95% confidence interval [ CI]) of a TPC was 0.4% (0.2-0.5%) and among SPCs 7.6% (4.4-10.8%). For TPCs, compared to matched patients, age-adjusted hazard ratio (95% CI) for death was 1.68 (0.77-3.67). The 10-year cumulative mortality of TPCs and matched patients was 92.6% and 67.9%, respectively. Conclusions: A clustering of tobacco-related cancers was observed in TPCs, with a 10-year cumulative incidence of 0.4% among FPCs. TPCs had worse survival than patients without a TPC.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5