Porous hydroxyapatite and glass reinforced hydroxyapatite for controlled release of sodium ampicillin

• Tipo: Artigo em Revista Científica Internacional
• Data: 2004

Autores

A. C. Queiroz (Autor) Outra; S. Teixeira (Autor) Outra; José Santos (Autor) FEUP; Fernando Jorge Monteiro (Autor) FEUP

Revista

Título: Bioceramics

Vol. 254-2

Páginas: 997-1000

Indexação

ISI Web of Knowledge - 11 Citações

ISI Web of Science

Scopus - 8 Citações

COMPENDEX

Classificação Científica

FOS: Ciências da engenharia e tecnologias > Biotecnologia ambiental

Outras Informações

ID Authenticus: P-000-CBT

DOI: 10.4028/www.scientific.net/KEM.254-256.997

Abstract (EN): Porous hydroxyapatite (HA) and glass reinforced hydroxyapatite (GRHA) with adequate macro and microporous structure were developed, aiming at being used as drug delivery carrier of antibiotics, for the in situ treatment of periodontitis. Materials were characterised by XRD and FTIR, presenting no changes from similar dense materials. Mercury intrusion porosimetry revealed micropores of less than 1 mum, accounting for 15% of the total porosity. Compression tests have shown close values for HA and GRHA, with the former showing slightly higher values of strength. Ampicillin adsorption was more effective on porous than on dense HA, and was similar for HA and GRHA.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 4