High-intensity infrasound effects on glucose metabolism in rats

• Tipo: Artigo em Revista Científica Internacional
• Data: 2021-08

Autores

Gonçalo Martins Pereira (Autor) Outra; Madalena Santos (Autor) ICBAS; Sofia S. Pereira (Autor) ICBAS; Francisco Tortosa (Autor) Outra; Gonçalo Borrecho (Autor) Outra; José Brito (Autor) Outra; Diamantino Freitas (Autor) Outra; António Oliveira de Carvalho (Autor) FEUP; Artur Águas (Autor) ICBAS; Maria João Oliveira (Autor) ICBAS; Pedro Oliveira (Autor) Outra

Revista

Título: Scientific Reports

Vol. 11

Páginas: 1-13

ISSN: 2045-2322

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 2 Citações

Scopus - 2 Citações

Classificação Científica

CORDIS: Ciências da Saúde > Ciências Médicas > Medicina ; Ciências Tecnológicas > Tecnologia > Tecnologia do som

Outras Informações

ID Authenticus: P-00V-ASJ

DOI: 10.1038/s41598-021-96796-5

Abstract (EN): Recent focus has been given on the effects of high-intensity infrasound (HII) exposure, and whether it induces changes in pancreatic morphology and glucose metabolism is still unknown. As such, we have studied the impact of HII exposure on glucose tolerance, insulin sensitivity, pancreatic islet morphology, muscle GLUT4 and plasma insulin and corticosterone levels. Normal and glucose intolerant wild-type Wistar rats were randomly divided in two groups: one group not exposed to HII and the other continuously exposed to HII. Animals were sacrificed at three timepoints of exposure (1, 6 or 12 weeks). An intraperitoneal glucose tolerance test was performed, blood samples were collected and the pancreas and the quadriceps femoris muscle were excised. Circulating insulin and corticosterone levels were determined and pancreatic and muscular tissue were routinely processed for histochemistry and immunohistochemistry with an anti-GLUT4 antibody. Animals exposed to HII had higher corticosterone levels than animals not exposed. No differences were found on insulin concerning HII exposure or glucose intolerance. Glucose intolerant animals had pancreatic islet fibrosis and no differences were found in GLUT4 ratio concerning HII exposure. In conclusion, we found that continuous exposure to HII increases stress hormone levels without inducing glucose intolerance in rats.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 12