Inefficiency of the anticoagulant therapy in the regression of the radiation-induced optic neuropathy in Cushing's disease

• Tipo: Artigo em Revista Científica Internacional
• Data: 1999

Autores

Barbosa, AP (Autor) Outra; Carvalho, Davide (Autor) Outra; Marques, L (Autor) Outra; Monteiro, M (Autor) Outra; Neves, AC (Autor) Outra; Carvalho, AM (Autor) Outra; Cruz, J (Autor) Outra; Medina, JL (Autor) Outra

Revista

Título: Journal of Endocrinological Investigation

Vol. 22

Páginas: 301-305

ISSN: 0391-4097

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 19 Citações

Scopus - 20 Citações

Outras Informações

ID Authenticus: P-001-4QP

DOI: 10.1007/bf03343560

Abstract (EN): Radiation-induced optic neuropathy is a rare complication (prevalence less than 1%) following radiotherapy of the sellar region. However, the vasculopathy in Cushing's disease predisposes to radiation-induced injury. We report the case of a 24-year-old man with Cushing's disease since he was 16. The hormonal study including bilateral inferior petrosal sinus catheterization diagnosed a pituitary right lesion, but imagiology was always negative. He underwent a transsphenoidal microadenomectomy and the pathological study showed the presence of corticotrophic hyperplasia but no adenoma. Secondary hypothyroidism and hypogonadism as well as permanent diabetes insipidus were diagnosed and because the patient was not cured he underwent a second transsphenoidal total hypophysectomy. After that and because he was still hypercortisolemic, pituitary external irradiation was given in a total dose of 6000 rad. Six months later he developed progressive bilateral visual loss. Cerebral MR revealed focal enhancement of the enlarged optic nerves and chiasm, associated with demyelination areas of the posterior visual pathways. Treatment was tried first with high doses of corticosteroids and later with anticoagulants-heparin EV. 1000 U/h during 7 days followed by warfarin, but unsuccessfully, probably because the patient was already amaurotic at the beginning of the last treatment. (J. Endocrinol. Invest. 22: 301-305, 1999) (C)1999, Editrice Kurtis.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5