Impact on Longevity of Genetic Cardiovascular Risk and Lifestyle including Red Meat Consumption

• Tipo: Artigo em Revista Científica Internacional
• Data: 2020

Autores

da Silva, AP (Autor) Outra; Costa, MD (Autor) Outra; Aguiar, L (Autor) Outra; Matos, A (Autor) Outra; Gil, A (Autor) Outra; Gorjao Clara, J (Autor) Outra; Polonia, J (Autor) FMUP; Bicho, M (Autor) Outra

Revista

Título: Oxidative Medicine and Cellular Longevity

Vol. 2020

Páginas: 1-14

ISSN: 1942-0900

Editora: Hindawi

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 1 Citação

Outras Informações

ID Authenticus: P-00S-G1Y

DOI: 10.1155/2020/1305413

Abstract (EN): Background. Cardiovascular risk (CVR) underlies aging process and longevity. Previous work points to genetic and environmental factors associated with this risk. Objectives. The aim of this research is to look for any CVR gene-gene and gene-multifactorial/lifestyle interactions that may impact health and disease and underlie exceptional longevity. Methods. A case-control study involving 521 both gender individuals, 253 centenarians (100.26 +/- 1.98 years), and 268 controls (67.51 +/- 3.25 years), low (LCR, n = 107) and high (HCR, n = 161) CVR. Hypertension, diabetes, obesity (BMI, kg.m(-2)), and impaired kidney function were defined according to standard criteria. CVR was calculated using Q risk (R). DNA was genotyping (ACE-rs4646994, AGT-rs4762, AGR1-rs5182, GRK4-rs2960306, GRK4-rs1024323, NOS3-rs1799983, and SLC12A3-rs13306673) through iPlex-MassARRAY (R), read by MALDI-TOF mass spectrometry, and analyzed by EARTDECODE (R). Results. Antilongevity factors consisted (OR 95% CI, p < 0.05) BMI 1.558 (1.445-1.680), hypertension 2.358 (1.565-3.553), smoking habits 4.528 (2.579-7.949), diabetes 5.553 (2.889-10.675), hypercholesterolemia 1.016 (1.010-1.022), and regular consumption of red meat 22.363 (13.987-35.755). Genetic aspects particularly for HCR individuals ACEII (OR: 3.96 (1.83-8.56), p < 0.0001) and NOS3 TT (OR: 3.11 (1.70-5.70), p < 0.0001) genotypes were also risk associate. Obesity, smoking, hypercholesterolemia, and frequent consumption of red meat have an additive action to hypertension in the longevity process. There was a synergistic interaction between the endothelial NOS3 genotypes and the severity of arterial hypertension. An epistatic interaction between functional genetic variants of GRK4 and angiotensinogen was also observed. Conclusions. Cardiovascular risk-related genetic and multifactorial or predominantly lifestyle aspects and its interactions might influence the aging process and contribute to exceptional longevity in Portuguese centenarians. Besides lifestyle, the activity of nitrite oxide synthase may be one of the main physiologic regulators of cardiovascular protection in the path of longevity.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 14