The Impact of Bariatric Surgery on Hepatic Function and Predictors of Liver Steatosis and Fibrosis

• Tipo: Artigo em Revista Científica Internacional
• Data: 2020

Autores

Borges Canha, M (Autor) FMUP; Neves, JS (Autor) FMUP; Mendonca, F (Autor) Outra; Silva, MM (Autor) Outra; Costa, C (Autor) Outra; Cabral, PM (Autor) Outra; Guerreiro, V (Autor) Outra; Lourenco, R (Autor) Outra; Meira, P (Autor) Outra; Salazar, D (Autor) Outra; Ferreira, MJ (Autor) Outra; Pedro, J (Autor) Outra; Leite, A (Autor) Outra; Viana, S (Autor) Outra; Sande, A (Autor) Outra; Belo, S (Autor) Outra; Lau, E (Autor) FMUP; Freitas, P (Autor) FMUP; Carvalho, Davide (Autor) FMUP

Revista

Título: Obesity Surgery

Vol. 30

Páginas: 2935-2941

ISSN: 0960-8923

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 12 Citações

Scopus - 12 Citações

Outras Informações

ID Authenticus: P-00S-1WQ

DOI: 10.1007/s11695-020-04622-0

Abstract (EN): Purpose To evaluate the variation in parameters of hepatic function and in the scores Fatty Liver Index (FLI; predictor of hepatic steatosis) and BARD (BMI, AST/ALT ratio and DM, predictor of hepatic fibrosis), 1 year after bariatric surgery. Material and Methods This is a observational retrospective cohort study in patients with morbid obesity that underwent bariatric surgery in our centre. We used two linear regression models: (1) unadjusted and (2) adjusted for surgery type, sex, age, body mass index, diabetes, and dyslipidaemia. Results The included population (n = 1955) had an average age of 43.1 +/- 10 years and 85.8% were female. Diabetes was present in 32.4% of the patients, 45.1% had dyslipidaemia, and 62.2% had hypertension. Twelve percent were submitted to gastric band, 29.6% to sleeve gastrectomy, and 58.4% to gastric bypass. We observed a relevant decrease in transaminases and gamma-glutamyltransferase, and an increase in alkaline phosphatase and total bilirubin. Both FLI and BARD markedly decrease 1 year after surgery (p < 0.01). Comparing the surgical procedures, sleeve gastrectomy was associated with a greater reduction of hepatic enzymes and of both FLI and BARD compared with gastric band. Comparing with gastric bypass, sleeve was associated with a greater reduction of transaminases and alkaline phosphatase, but a smaller reduction of FLI and BARD. Conclusion Bariatric surgery is associated with a reduction of the hepatic enzymes and an improvement of FLI and BARD. It may represent an effective therapeutic approach for NAFLD.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7