Psychopathological dimensions in subjects with hereditary ATTR V30M amyloidosis and their relation with life events due to the disease

• Tipo: Artigo em Revista Científica Internacional
• Data: 2018

Autores

Lopes, A (Autor) Outra; Fonseca, I (Autor) Outra; Sousa, A (Autor) Outra; Rodrigues, C (Autor) Outra; Branco, M (Autor) Outra; Coelho, T (Autor) Outra; Sequeiros, J (Autor) Outra; Freitas, P (Autor) Outra

Revista

Título: Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis

Vol. 25

Páginas: 26-36

ISSN: 1350-6129

Editora: Taylor & Francis

Indexação

ISI Web of Knowledge - 6 Citações

Scopus - 7 Citações

Outras Informações

ID Authenticus: P-00N-SZM

DOI: 10.1080/13506129.2018.1428795

Abstract (EN): Background: Chronic physical illness has been associated with emotional distress. Chronic diseases may change usual family patterns with economic, social and family losses. Hereditary ATTR V30M amyloidosis is a rare, fatal inherited systemic amyloidosis, with chronic evolution and beginning in adulthood.Aims and methods: To evaluate psychopathological dimensions and how they correlated with disease-related life events, 209 symptomatic and asymptomatic carriers, participated in the study. Sociodemographic and Family and Personal History Disease questionnaires and brief symptom inventory (BSI) were applied.Results: BSI indices, global severity index (GSI), positive symptom index (PSI) and positive symptom total (PST) scored higher than general population. Independent predictors for GSI >0.83 were female sex (OR=3.46, p=.005) and being symptomatic carriers (OR=3.03, p=.039). Independent predictors of a PST >26.99 were female sex (OR=3.74, p=.012) symptomatic carrier (OR=5.32, p=.025), age between 15 and 24years at affected parent's death (OR=5.26, p=.04). Independent predictors of a PSI >1.56 were being asymptomatic carrier (OR=6.3, p=.036); to have children (OR=3.19, p=.043) and have14years at parent's disease onset (OR=6.39, p=.05).Conclusions: Results point to an important vulnerability of this population for psychological distress and psychiatric disease. Early life events related to disease, being sick and sex are associated with psychopathological distress.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 11