Gut Microbiota: Association with NAFLD and Metabolic Disturbances

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2015

Autores

Lau, E (Autor) Outra; Carvalho, Davide (Autor) FMUP; Freitas, P (Autor) FMUP

Revista

Título: BioMed Research International

Vol. 2015 Nº ID 531789

Páginas: 1-9

ISSN: 2314-6133

Editora: Hindawi

Indexação

ISI Web of Knowledge - 45 Citações

Scopus - 48 Citações

Outras Informações

ID Authenticus: P-00G-BB0

DOI: 10.1155/2015/979515

Abstract (EN): Nonalcoholic fatty liver disease is the hepatic expression of metabolic syndrome, being frequently associated with obesity, insulin resistance, and dyslipidemia. Recent lines of evidence have demonstrated a role of gut microbiota in insulin resistance, obesity, and associated metabolic disturbances, raising the interest in its relationship with NAFLD pathogenesis. Therefore, intestinal microbiota has emerged as a potential factor involved in NAFLD, through different pathways, including its influence in energy storage, lipid and choline metabolism, ethanol production, immune balance, and inflammation. The main objective of this review is to address the pathogenic association of gut microbiota to NAFLD. This comprehension may allow the development of integrated strategies to modulate intestinal microbiota in order to treat NAFLD.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9