Bonelike (R)/PLGA hybrid materials for bone regeneration: Preparation route and physicochemical characterisation

• Tipo: Artigo em Revista Científica Internacional
• Data: 2005

Autores

Oliveira, JM (Autor) Outra; Miyazaki, T (Autor) Outra; Lopes, MA (Autor) FEUP; Ohtsuki, C (Autor) Outra; Santos, JD (Autor) FEUP

Revista

Título: Journal of Materials Science: Materials in Medicine

Vol. 16

Páginas: 253-259

ISSN: 0957-4530

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 16 Citações

ISI Web of Science

Scopus - 20 Citações

Classificação Científica

FOS: Ciências da engenharia e tecnologias > Biotecnologia ambiental

CORDIS: Ciências Tecnológicas > Engenharia > Engenharia biomédica

Outras Informações

ID Authenticus: P-000-4HV

DOI: 10.1007/s10856-005-6687-y

Abstract (EN): Bonelike(R)/PLGA hybrid materials have been developed using. gamma-MPS as silane-coupling agent between the inorganic and organic phases for controlled drug delivery applications. Silanization showed to be more effective when cyclohexane was used as a non-polar solvent (nP method) due to a chemical interaction between Bonelike(R) and the silane film, while by using a 95/5 (V/V) methanol/water as a polar solvent ( P method), a much thinner film was achieved. Functional groups of PLGA, such as the carbonyl group ( C = O), were identified using Raman and FTIR-ATR analysis and therefore these groups may be used to link therapeutic molecules. These novel hybrid materials prepared by combining silanization and post-hybridisation processes are expected to find use in medical applications of bone regeneration and as drug delivery carrier for therapeutic molecules. (C) 2005 Springer Science + Business Media, Inc.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7