Choroidal neovascularization secondary to pathological myopia-macular Bruch membrane defects as prognostic factor to anti-VEGF treatment

• Tipo: Artigo em Revista Científica Internacional
• Data: 2021

Autores

Coelho, J (Autor) Outra; Ferreira, A (Autor) FMUP; Abreu, AC (Autor) Outra; Monteiro, S (Autor) Outra; Furtado, MJ (Autor) Outra; Gomes, M (Autor) Outra; Lume, M (Autor) Outra

Revista

Título: Graefe's Archive for Clinical and Experimental Ophthalmology

Vol. 259

Páginas: 2679-2686

ISSN: 0721-832X

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 2 Citações

Scopus - 2 Citações

Outras Informações

ID Authenticus: P-00T-P6N

DOI: 10.1007/s00417-021-05142-y

Abstract (EN): Purpose To evaluate the prevalence and visual outcomes of macular Bruch membrane (BM) defects in patients treated with anti-vascular endothelial growth factors (VEGF) for choroidal neovascularization secondary to pathological myopia (mCNV). Methods Single-center retrospective observational case series of 68 eyes from 62 patients with mCNV treated with one anti-VEGF injection followed by a pro re nata (1 + PRN) regimen. A minimum follow-up of 6 months was defined. Chorioretinal atrophy was assessed by fundus examination, fluorescein angiography, and SD-OCT. Results Median follow-up was 28.5 (range 6-89) months with a median number of 5 anti-VEGF injections. At baseline, 27.9% of eyes had macular BM defects increasing to 36.8% during follow-up (p<0.001). Eyes without macular BM defects at the baseline had higher BCVA at the last observation than patients with BM defects (p=0.003). An increase of 5 or more ETDRS letters was more frequent in eyes without BM defects (p=0.001). At the end of follow-up, mCNV-related macular atrophy was present in 44.1%; out of which, 83.3% presented macular BM defects (p<0.001). Eyes with mCNV-related macular atrophy without BM defects had a significant increase of best-corrected visual acuity compared with eyes with mCNV-related macular atrophy and BM defect (p=0.002). Conclusions Macular Bruch membrane defects are often seen in mCNV and have a significant impact in visual acuity and prognosis. Eyes with macular BM defects have a poorer response and worse visual outcomes after anti-VEGF therapy.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8