Opinion on moderate/low cancer genetic risk markers in medical practice including comment on the article Genetic contribution to all cancers: the first demonstration using the model of breast cancers from Poland stratified by age at diagnosis and tumour pathology by Lubinski et al., Breast Cancer Res Treat 2008 Apr 15

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2008

Autores

Costa, S (Autor) Outra; Fernando Schmitt (Autor) FMUP

Revista

Título: Hereditary Cancer in Clinical Practice

Vol. 34

Páginas: 64-65

ISSN: 1731-2302

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-003-YGZ

DOI: 10.1186/1897-4287-6-2-64

Abstract (EN): [Excerpt] Breast cancer is a heterogeneous disease characterized by a widely variable morphological appearance, many risk factors and distinct gene expression profiles [1, 2]. Common genetic alterations (e.g. polymorphisms), with possible effects on protein function and/or expression, within genes involved in essential cellular pathways, such as carcinogen metabolism, DNA repair, cell cycle control and cell proliferation, can predispose individuals to various tumours, including breast cancer [3-7]. [...]

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 2