VEGFR-3 expression in breast cancer tissue is not restricted to lymphatic vessels

• Tipo: Artigo em Revista Científica Internacional
• Data: 2005

Autores

Filho, AL (Autor) Outra; Martins, A (Autor) Outra; Costa, SMA (Autor) Outra; Fernando Schmitt (Autor) FMUP

Revista

Título: Pathology Research and Practice

Vol. 201

Páginas: 93-99

ISSN: 0344-0338

Editora: Elsevier

Indexação

ISI Web of Knowledge - 26 Citações

Scopus - 39 Citações

Outras Informações

ID Authenticus: P-000-6D5

DOI: 10.1016/j.prp.2004.11.008

Abstract (EN): We examined the immunohistochemical reactivity for vascular endothelial growth factor receptor 3 (VEGFR-3), a protein playing an important role in lymphangiogenesis, in breast cancer. A retrospective series of 77 invasive ductal breast carcinomas was investigated. The relationship between VEGFP-3 expression and clinicopathologic parameters was examined for statistical significance using Pearson's chi-square (x(2)) test and Fisher's exact test (when n < 5). Threshold for significance was p < 0.05. Patient age ranged from 31 to 77 years (mean: 55 years). The VEGFR-3 immunoreactivity was as follows: 5 cases were negative (6.5%)., 35 + (45.4%), 27 + + (35.1%), and 10+++ (13.0%). Reactions were positive for both lymphatic and blood vessels in several cases. VEGFR-3-positive reactions were more frequent in the tumor periphery than within the tumor. Immunoreactivity was also observed in myoepithelial cells surrounding both normal ducts and ducts with ductal carcinoma in situ. Statistical analysis of VEGFR-3 reactions was not significantly related to node status, microvessel density, and tumor grade. Ploidy showed a tendency towards significance (p = 0.063); however, owing to the limited number of cases, statistical significance was not reached. VEGFR-3 lacks lymphatic vessel specificity and is also expressed in blood vessels, myoepithelial cells, and neoplastic cells.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7