P-cadherin expression in glandular lesions of the uterine cervix detected by liquid-based cytology

• Tipo: Artigo em Revista Científica Internacional
• Data: 2005

Autores

Longatto Filho, A (Autor) Outra; Albergaria, A (Autor) Outra; Joana Paredes (Autor) Outra; Moreira, MAR (Autor) Outra; Milanezi, F (Autor) Outra; Fernando Schmitt (Autor) FMUP

Revista

Título: Cytopathology

Vol. 16

Páginas: 88-93

ISSN: 0956-5507

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 11 Citações

Scopus - 12 Citações

Outras Informações

ID Authenticus: P-000-3YV

DOI: 10.1111/j.1365-2303.2004.00226.x

Abstract (EN): Objective: To study P-cadherin aberrant expression as a possible marker for cervical adenocarcinomas in cytological samples. Methods: We studied P-cadherin immunoexpression in liquid-based cervical cytology samples of biopsy-proven cervical lesions. Results: We found a statistically significant correlation between P-cadherin expression and a cytological diagnosis of malignancy, either glandular or squamous (P < 0.0001). Twenty-two of 33 malignant cases showed P-cadherin membrane staining. None of the 30 benign cases tested showed membrane staining, but three of them displayed an aberrant nuclear P-cadherin expression. Conclusions: We concluded that P-cadherin can be used to discriminate between malignant and benign cervical cytological specimens, but not to discriminate glandular from squamous lesions.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6