A reciprocal tensin-3-cten switch mediates EGF-driven mammary cell migration

• Tipo: Artigo em Revista Científica Internacional
• Data: 2007

Autores

Katz, M (Autor) Outra; Amit, I (Autor) Outra; Citri, A (Autor) Outra; Shay, T (Autor) Outra; Carvalho, S (Autor) Outra; Lavi, S (Autor) Outra; Milanezi, F (Autor) Outra; Lyass, L (Autor) Outra; Amariglio, N (Autor) Outra; Jacob Hirsch, J (Autor) Outra; Ben Chetrit, N (Autor) Outra; Tarcic, G (Autor) Outra; Lindzen, M (Autor) Outra; Avraham, R (Autor) Outra; Liao, YC (Autor) Outra; Trusk, P (Autor) Outra; Lyass, A (Autor) Outra; Rechavi, G (Autor) Outra; Spector, NL (Autor) Outra; Lo, SH (Autor) Outra; Fernando Schmitt (Autor) FMUP; Bacus, SS (Autor) Outra; Yarden, Y (Autor) Outra

Revista

Título: Nature Cell Biology

Vol. 9

Páginas: 961-U124

ISSN: 1465-7392

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 157 Citações

Scopus - 161 Citações

Outras Informações

ID Authenticus: P-004-8KQ

DOI: 10.1038/ncb1622

Abstract (EN): Cell migration driven by the epidermal growth factor receptor ( EGFR) propels morphogenesis(1) and involves reorganization of the actin cytoskeleton(2). Although de novo transcription precedes migration(3,4), transcript identity remains largely unknown. Through their actin-binding domains, tensins link the cytoskeleton to integrin-based adhesion sites(5). Here we report that EGF downregulates tensin-3 expression, and concomitantly upregulates cten, a tensin family member that lacks the actin-binding domain(6). Knockdown of cten or tensin-3, respectively, impairs or enhances mammary cell migration. Furthermore, cten displaces tensin-3 from the cytoplasmic tail of integrin beta(1), thereby instigating actin fibre disassembly. In invasive breast cancer, cten expression correlates not only with high EGFR and HER2, but also with metastasis to lymph nodes. Moreover, treatment of inflammatory breast cancer patients with an EGFR/HER2 dual-specificity kinase inhibitor significantly downregulated cten expression. In conclusion, a transcriptional tensin-3-cten switch may contribute to the metastasis of mammary cancer.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 14