P-cadherin expression in canine mammary tissues

• Tipo: Artigo em Revista Científica Internacional
• Data: 2004

Autores

Gama, A (Autor) Outra; Joana Paredes (Autor) Outra; Albergaria, A (Autor) Outra; Gartner, R (Autor) Outra; Fernando Schmitt (Autor) FMUP

Revista

Título: Journal of Comparative Pathology

Vol. 130

Páginas: 13-20

ISSN: 0021-9975

Editora: Elsevier

Indexação

ISI Web of Knowledge - 20 Citações

Scopus - 25 Citações

Outras Informações

ID Authenticus: P-000-D1N

DOI: 10.1016/s0021-9975(03)00064-1

Abstract (EN): P-cadherin is a classical cadherin expressed by myoepithelial cells in mammary tissue. Its expression in human breast cancer has been associated with aggressive tumour behaviour. To analyse the possible role of P-cadherin in canine mammary carcinogenesis, its expression was examined immunohistochemically in 82 samples of normal (n = 2), hyperplastic (n = 11) and neoplastic (n = 69) canine mammary tissues. In normal and hyperplastic canine mammary glands, P-cadherin was restricted to myoepithelial cells, usually, at sites of cell-to-cell contact. In tumour tissues, however, P-cadherin expression was observed in both epithelial and myoepithelial cells, with a cytoplasmic pattern of cellular distribution. Aberrant epithelial P-cadherin immunolabelling was found in 19/44 (43%) benign tumours and in 16/25 (64%) malignant tumours (P < 0.001). In malignant tumours, a significant correlation between P-cadherin expression intensity and histological type was observed (P < 0.05).

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8