Prognostic significance of monocarboxylate transporter expression in oral cavity tumors

• Tipo: Artigo em Revista Científica Internacional
• Data: 2016

Autores

Simoes Sousa, S (Autor) Outra; Granja, S (Autor) Outra; Pinheiro, C (Autor) Outra; Fernandes, D (Autor) Outra; Longatto, A (Autor) Outra; Laus, AC (Autor) Outra; Alves, CDC (Autor) Outra; Suarez Penaranda, JM (Autor) Outra; Perez Sayans, M (Autor) Outra; Carvalho, AL (Autor) Outra; Fernando Schmitt (Autor) FMUP; Garcia Garcia, A (Autor) Outra; Baltazar, F (Autor) Outra

Revista

Título: Cell Cycle

Vol. 15

Páginas: 1865-1873

ISSN: 1538-4101

Editora: Taylor & Francis

Indexação

ISI Web of Knowledge - 34 Citações

Scopus - 37 Citações

Outras Informações

ID Authenticus: P-00K-WXB

DOI: 10.1080/15384101.2016.1188239

Abstract (EN): Background: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common type of cancer. The majority of patients present advanced stage disease and has poor survival. Therefore, it is imperative to search for new biomarkers and new alternative and effective treatment options. Most cancer cells rely on aerobic glycolysis to generate energy and metabolic intermediates. This phenotype is a hallmark of cancer, characterized by an increase in glucose consumption and production of high amounts of lactate. Consequently, cancer cells need to up-regulate many proteins and enzymes related with the glycolytic metabolism. Thus, the aim of this study was to characterize metabolic phenotype of oral cavity cancers (OCC) by assessing the expression pattern of monocarboxylate transporters (MCTs) 1, 2 and 4 and other proteins related with the glycolytic phenotype. Material and Methods: We evaluated the immunohistochemical expression of MCT1, MCT4, CD147, GLUT1 and CAIX in 135 human samples of OCC and investigated the correlation with clinicopathological parameters and the possible association with prognosis. Results: We observed that all proteins analyzed presented significantly higher plasma membrane expression in neoplastic compared to non-neoplastic samples. MCT4 was significantly associated with T-stage and advanced tumoral stage, while CD147 was significantly correlated with histologic differentiation. Interestingly, tumors expressing both MCT1 and MCT4 but negative for MCT2 were associated with shorter overall survival. Conclusion: Overexpression of MCT1/4, CD147, GLUT1 and CAIX, supports previous findings of metabolic reprograming in OCC, warranting future studies to explore the hyper-glycolytic phenotype of these tumors. Importantly, MCT expression revealed to have a prognostic value in OCC survival.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9