Taking advantage of basic research: p63 is a reliable myoepithelial and stem cell marker

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2002

Autores

Reis Filho, JS (Autor) Outra; Fernando Schmitt (Autor) FMUP

Revista

Título: Advances in Anatomic Pathology

Vol. 9

Páginas: 280-289

ISSN: 1072-4109

Editora: Wolters Kluwer Health

Indexação

Scopus - 76 Citações

Outras Informações

ID Authenticus: P-00F-GYG

DOI: 10.1097/01.pap.0000027919.62579.52

Abstract (EN): p63 is a recently characterized p53-homolog that is consistently expressed by basal/somatic stem cells of stratified epithelia, myoepithelial cells of the breast and salivary glands, and proliferative compartment of gastric mucosa. p63 is located on the long arm of chromosome 3 (3q27) and it encodes six isoforms, three transactivating (TA) and three ¿N-isoforms. While the first three isoforms may act as tumor suppressor genes, the ¿N-isoforms may inhibit the p53/TA-p63-driven cell cycle arrest and apoptosis. Recently, the putative applications of p63 in the identification of myoepithelial cells of the breast and basal cells of the prostate acini have been evaluated; however, no critical systematic analysis of its role in surgical pathology practice have hitherto been reported. We review the putative roles of p63 in surgical pathology practice and provide guidelines for future directions on p63 translational research. © 2002 Lippincott Williams & Wilkins, Inc.

Idioma: Inglês

Tipo (Avaliação Docente): Científica