Prevalence of auto-antibodies associated to pulmonary arterial hypertension Cheek for in scleroderma - A review

• Tipo: Artigo em Revista Científica Internacional
• Data: 2018

Autores

José Pedro Nunes (Autor) FMUP; Cunha, AC (Autor) Outra; Meirinhos, T (Autor) Outra; Nunes, A (Autor) Outra; Araujo, PM (Autor) Outra; Godinho, AR (Autor) Outra; Vilela, EM (Autor) Outra; Carlos Vaz (Autor) FMUP

Revista

Título: Autoimmunity Reviews

Vol. 17

Páginas: 1186-1201

ISSN: 1568-9972

Editora: Elsevier

Indexação

ISI Web of Knowledge - 42 Citações

Scopus - 43 Citações

Outras Informações

ID Authenticus: P-00P-TND

DOI: 10.1016/j.autrev.2018.06.009

Abstract (EN): The prevalence of auto-antibodies associated to pulmonary arterial hypertension in scleroderma patients was reviewed, based on reports cited in two major scientific databases. Data were collected on the following types of antibodies: antinuclear, anti-double-stranded DNA, anticentromere, anti-CENP-A, anti-CENP-B, anti-bicaudal D2, anti-nucleolar, anti-Scl-70 (anti-topoisomerase I), anti-topoisomerase II alpha, anti-RNP, anti-U1RNP, anti-U3RNP, anti-RNA polymerase III, anti-Th/To, anti-histone, antiphospholipid, anti-PmScl, anti-Sm, anti SSA (anti-Ro),anti SSB (La), anti-Ro52 (TRIM 21), anti-Ku, anti-B23, anti-RuvBL1, anti-RuvBL2, anti-fibrin bound tissue plasminogen activator, anti-endothelial cell, anti-phosphatidylserine-prothrombin complex, anti-endothelin-1 type A receptor, anti-angiotensin II type 1 receptor, anti-carbonic anhydrase II, anti-fibroblast, anti-cyclic citrullinated peptide, anti-4-sulfated N-Acetyl-lactosamine, class I and II anti-human leukocyte antigen. Auto-antibodies were shown by different authors to be associated to this condition, with different prevalence values for each type of auto-antibody. Antinuclear antibodies, anti-centromere antibodies, antiphospholipid antibodies, anti-U3 RNP antibodies and anti-Th/To antibodies would appear to show a particularly important prevalence in scleroderma patients with pulmonary hypertension, appearing in about 8/10 (antinuclear), 1/2 (anti-centromere, anti-phospholipid), and 1/4 (anti-U3RNP, anti-Th/To) of patients. The available evidence points in the direction of a strong association between auto-immune mechanisms and pulmonary hypertension in the setting of scleroderma.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 16