EVIDENCE THAT CHLOROETHYLCLONIDINE CAN CONTRACT THE DOG SAPHENOUS-VEIN VIA A PROTEIN KINASE-C-DEPENDENT MECHANISM

• Tipo: Artigo em Revista Científica Internacional
• Data: 1994

Autores

José Pedro Nunes (Autor) FMUP; Alberto Mota (Autor) FMUP

Revista

Título: Archives Internationales de Pharmacodynamie et de Therapie

Vol. 327

Páginas: 142-151

ISSN: 0003-9780

Editora: Blackwell

Indexação

ISI Web of Knowledge - 1 Citação

Scopus - 2 Citações

Outras Informações

ID Authenticus: P-001-KAA

Abstract (EN): Chloroethylclonidine has recently been shown to produce concentration-dependent contractions in the dog saphenous vein. These contractions are very sensitive to cooling, yohimbine and rauwolscine, and moderately sensitive to prazosin. The effects of compound H-7 (a protein kinase inhibitor) and isradipine (a calcium channel blocker) on the contractions to chloroethylclonidine, UK14304 and phenylephrine were studied in the dog saphenous vein. Compound H-7 (20 mumol/l) produced a very marked (85 %) inhibition of chloroethylclonidine-induced contractions, a moderate (48 %) inhibition of UK14304-induced contractions and a slight (19 %) inhibition of phenylephrine-induced contractions. Isradipine (1 mumol/l) produced a moderate (49 %) inhibition of chloroethylclonidine-induced contractions and a slight (15 %) inhibition of phenylephrine-induced contractions. Phorbol 12,13-dibutyrate (1 mumol/l) produced a contraction that reached 61.1 +/- 3.2 % of the maximum and was inhibited moderately (46 %) by compound H-7. It is suggested that, in the dog saphenous vein, the receptor activated by chloroethylclonidine may be coupled to protein kinase C.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10