Antimicrobial Peptides: Identification of two Beta-Defensins in a Teleost Fish, the European Sea Bass (Dicentrarchus labrax)

• Tipo: Artigo em Revista Científica Internacional
• Data: 2021

Autores

Barroso, C (Autor) Outra; Carvalho, P (Autor) Outra; goncalves, j (Autor) ICBAS; Rodrigues, P (Autor) ICBAS; Neves, JV (Autor) Outra

Revista

Título: Pharmaceuticals

Vol. 14

Página Final: 566

ISSN: 1424-8247

Editora: MDPI

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-00V-46A

DOI: 10.3390/ph14060566

Abstract (EN): Beta-defensins consist in a group of cysteine-rich antimicrobial peptides (AMPs), widely found throughout vertebrate species, including teleost fish, with antimicrobial and immunomodulatory activities. However, although the European sea bass (Dicentrarchus labrax) is one of the most commercially important farmed fish species in the Mediterranean area, the characterization of its beta-defensins and its potential applications are still missing. In this study, we characterized two members of the beta-defensin family in this species. Phylogenetic and synteny analysis places sea bass peptides in the beta-defensin subfamilies 1 and 2, sharing similar features with the other members, including the six cysteines and the tertiary structure, that consists in three antiparallel beta-sheets, with beta-defensin 1 presenting an extra alpha-helix at the N-terminal. Further studies are necessary to uncover the functions of sea bass beta-defensins, particularly their antimicrobial and immunomodulatory properties, in order to develop novel prophylactic or therapeutic compounds to be used in aquaculture production.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 16