Antimicrobial Peptides as Potential Anti-Tubercular Leads: A Concise Review

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2021

Autores

Oliveira, GS (Autor) Outra; Costa, RP (Autor) Outra; Paula Gomes (Autor) FCUP; Gomes, MS (Autor) ICBAS; Silva, T (Autor) Outra; Catia Teixeira (Autor) FCUP

Revista

Título: Pharmaceuticals

Vol. 14

Página Final: 323

ISSN: 1424-8247

Editora: MDPI

Indexação

ISI Web of Knowledge - 16 Citações

Scopus - 16 Citações

Outras Informações

ID Authenticus: P-00T-QPQ

DOI: 10.3390/ph14040323

Abstract (EN): Despite being considered a public health emergency for the last 25 years, tuberculosis (TB) is still one of the deadliest infectious diseases, responsible for over a million deaths every year. The length and toxicity of available treatments and the increasing emergence of multidrug-resistant strains of Mycobacterium tuberculosis renders standard regimens increasingly inefficient and emphasizes the urgency to develop new approaches that are not only cost- and time-effective but also less toxic. Antimicrobial peptides (AMP) are small cationic and amphipathic molecules that play a vital role in the host immune system by acting as a first barrier against invading pathogens. The broad spectrum of properties that peptides possess make them one of the best possible alternatives for a new "post-antibiotic" era. In this context, research into AMP as potential anti-tubercular agents has been driven by the increasing danger revolving around the emergence of extremely-resistant strains, the innate resistance that mycobacteria possess and the low compliance of patients towards the toxic anti-TB treatments. In this review, we will focus on AMP from various sources, such as animal, non-animal and synthetic, with reported inhibitory activity towards Mycobacterium tuberculosis.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 20