Transient receptor potential channels in bladder function

• Tipo: Artigo em Revista Científica Internacional
• Data: 2013

Autores

Avelino, A. (Autor) Outra; Charrua, Ana (Autor) FCNAUP; Frias, B. (Autor) Outra; Cruz, C. (Autor) Outra; Boudes, M. (Autor) Outra; de Ridder, D. (Autor) Outra; Cruz, F. (Autor) Outra

Revista

Título: Acta Physiologica

Vol. 207 Nº 1

Páginas: 110-122

ISSN: 1748-1708

Indexação

ISI Web of Science

Classificação Científica

FOS: Ciências médicas e da saúde > Ciências da saúde

CORDIS: Ciências da Saúde

Outras Informações

Abstract (EN): The transient receptor potential (TRP) superfamily of cationic ion channels includes proteins involved in the transduction of several physical and chemical stimuli to finely tune physiological functions. In the urinary bladder, they are highly expressed in, but not restricted to, primary afferent neurons. The urothelium and some interstitial cells also express several TRP channels. In this review, we describe the expression and the known roles of some members of TRP subfamilies, namely TRPV, TRPM and TRPA, in the urinary bladder. The therapeutic interest of modulating the activity of TRP channels to treat bladder dysfunctions is also discussed.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

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