Potent and selective MAO-B inhibitory activity: Amino- versus nitro-3-arylcoumarin derivatives

• Tipo: Artigo em Revista Científica Internacional
• Data: 2015

Autores

Matos, MJ (Autor) Outra; Rodríguez Enríquez, F (Autor) Outra; Vilar, S (Autor) Outra; Santana, L (Autor) Outra; Uriarte, E (Autor) Outra; Hripcsak, G (Autor) Outra; Estrada, M (Autor) Outra; Rodríguez Franco, MI (Autor) Outra; Viña, D (Autor) Outra

Revista

Título: Bioorganic and Medicinal Chemistry Letters

Vol. 25

Páginas: 642-648

ISSN: 0960-894X

Editora: Elsevier

Indexação

Scopus - 18 Citações

Outras Informações

ID Authenticus: P-00R-0N9

DOI: 10.1016/j.bmcl.2014.12.001

Abstract (EN): In this study we synthesized and evaluated a new series of amino and nitro 3-arylcoumarins as hMAO-A and hMAO-B inhibitors. Compounds 2, 3, 5 and 6 presented a better activity and selectivity profile against the hMAO-B isoform (IC<inf>50</inf> values between 2 and 6 nM) than selegiline. In general, the amino derivatives (4-6) proved to be more selective against MAO-B than the nitro derivatives (1-3). Additionally, a theoretical study of some physicochemical properties, PAMPA and reversibility assays for the most potent derivative, and molecular docking simulations were carried out to further explain the pharmacological results, and to identify the hypothetical binding mode for the compounds inside the hMAO-B.

Idioma: Inglês

Tipo (Avaliação Docente): Científica