Lesion of the caudal ventrolateral medulla prevents the induction of hypertension by adenosine receptor blockade in rats

• Tipo: Artigo em Revista Científica Internacional
• Data: 2006

Autores

Pinho, D (Autor) Outra; Sousa, T (Autor) FFUP; Morato, M (Autor) FFUP; Tavares, I (Autor) FMUP; Albino Teixeira, A (Autor) FMUP

Revista

Título: Brain Research

Vol. 1073

Páginas: 374-382

ISSN: 0006-8993

Editora: Elsevier

Indexação

ISI Web of Knowledge - 7 Citações

ISI Web of Science

Scopus - 7 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

CORDIS: Ciências da Saúde > Neurociências > Neurobiologia

Outras Informações

ID Authenticus: P-004-N8B

DOI: 10.1016/j.brainres.2005.12.098

Abstract (EN): The continuous infusion for 7 days of the adenosine receptor antagonist 1,3-dipropyl-8sulfophenylxanthine (DPSPX) causes a sustained hypertension in rats, with an enhancement of sympathetic neurotrans mission and activation of the renin-angiotensin system. We studied the involvement of the caudal ventrolateral medulla in the establishment of this hypertensive model by evaluating the effect of local lesioning in blood pressure (BP). Male adult Wistar rats received stereotaxic injections of 0.3 mu l of saline or quinolinic acid (QA; 180 mM) in the caudal ventrolateral medulla followed by abdominal implant of minipump for infusion of saline or DPSPX (90 mu g(-1) kg(-1) h(-1)). BP was measured in conscious animals every 2 days for 12 days. The sustained increase of BP (22.1 mm Hg; P < 0.001) detected in rats infused with DPSPX was reverted (6.7 mm Hg; P > 0.05) from day six onwards in animals with lesion of the lateralmost part of caudal ventrolateral medulla (VLMIat). The present results suggest that the development of hypertension induced by adenosine receptor antagonist involves the participation of the VLMlat. They further add new data as to the functional complexity of this medullary area involved in a variety of functions such as cardiovascular, respiratory, motor and pain control.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9