The diagnosis and management of pre-invasive breast disease - Genetic alterations in pre-invasive lesions

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2003

Autores

Frazao, O (Autor) Outra; Lakhani, SR (Autor) Outra

Revista

Título: Breast Cancer Research

Vol. 5

Páginas: 313-319

ISSN: 1465-5411

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 98 Citações

Scopus - 114 Citações

Outras Informações

ID Authenticus: P-000-J96

DOI: 10.1186/bcr650

Abstract (EN): The development of modern molecular genetic techniques has allowed breast cancer researchers to clarify the multistep model of breast carcinogenesis. Laser capture microdissection coupled with comparative genomic hybridisation and/or loss-of-heterozygosity methods have confirmed that many pre-invasive lesions of the breast harbour chromosomal abnormalities at loci known to be altered in invasive breast carcinomas. Current data do not provide strong evidence for ductal hyperplasia of usual type as a precursor lesion, although some are monoclonal proliferations; however, atypical hyperplasia and in situ carcinoma appear to be nonobligate precursors. We review current knowledge and the contribution of molecular genetics in the understanding of breast cancer precursors and pre-invasive lesions.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7