POST-NOAC: Portuguese observational study of intracranial hemorrhage on non-vitamin K antagonist oral anticoagulants

• Tipo: Artigo em Revista Científica Internacional
• Data: 2017

Autores

Marques Matos, C (Autor) Outra; Alves, JN (Autor) Outra; Marto, JP (Autor) Outra; Ribeiro, JA (Autor) Outra; Monteiro, A (Autor) Outra; Araujo, J (Autor) Outra; Silva, F (Autor) Outra; Grenho, F (Autor) Outra; Viana Baptista, M (Autor) Outra; Sargento Freitas, J (Autor) Outra; Pinho, J (Autor) Outra; Elsa Azevedo (Autor) FMUP

Revista

Título: International Journal of Stroke

Vol. 12

Páginas: 623-627

ISSN: 1747-4930

Editora: SAGE

Indexação

ISI Web of Knowledge - 15 Citações

Scopus - 16 Citações

Outras Informações

ID Authenticus: P-00R-ANB

DOI: 10.1177/1747493016681021

Abstract (EN): Background: There is a lower reported incidence of intracranial hemorrhage with non-vitamin K antagonist oral anticoagulants compared with vitamin K antagonist. However, the functional outcome and mortality of intracranial hemorrhage patients were not assessed. Aims: To compare the outcome of vitamin K antagonists-and non-vitamin K antagonist oral anticoagulants-related intracranial hemorrhage. Methods: We included consecutive patients with acute non-traumatic intracranial hemorrhage on oral anticoagulation therapy admitted between January 2013 and June 2015 at four university hospitals. Clinical and demographic data were obtained from individual medical records. Intracranial hemorrhage was classified as intracerebral, extra-axial, or multi-focal using brain computed tomography. Three-month functional outcome was assessed using the modified Rankin Scale. Results: Among 246 patients included, 24 (9.8%) were anticoagulated with a non-vitamin K antagonist oral anticoagulants and 222 (90.2%) with a vitamin K antagonists. Non-vitamin K antagonist oral anticoagulants patients were older (81.5 vs. 76 years, p = 0.048) and had intracerebral hemorrhage more often (83.3% vs. 63.1%, p = 0.048). We detected a non-significant trend for larger intracerebral hemorrhage volumes in vitamin K antagonists patients (p = 0.368). Survival analysis adjusted for age, CHA(2)DS(2)VASc, HAS-BLED, and anticoagulation reversal revealed that non-vitamin K antagonist oral anticoagulants did not influence three-month mortality (hazard ratio (HR) = 0.83, 95% confidence interval (CI) = 0.39-1.80, p = 0.638). Multivariable ordinal regression for three-month functional outcome did not show a significant shift of modified Rankin Scale scores in non-vitamin K antagonist oral anticoagulants patients (odds ratio (OR) 1.26, 95% CI 0.55-2.87, p = 0.585). Conclusions: We detected no significant differences in the three-month outcome between non-vitamin K antagonist oral anticoagulants-and vitamin K antagonists-associated intracranial hemorrhage, despite unavailability of non-vitamin K antagonist oral anticoagulants-specific reversal agents.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5