Cerebral autoregulation is preserved in multiple sclerosis patients

• Tipo: Artigo em Revista Científica Internacional
• Data: 2017

Autores

Ferreira, D (Autor) Outra; Pedro Castro (Autor) FMUP; Videira, G (Autor) Outra; Filipe, JP (Autor) Outra; Santos, R (Autor) Outra; Sa, MJ (Autor) Outra; Elsa Azevedo (Autor) FMUP; Pedro Abreu (Autor) FMUP

Revista

Título: Journal of the Neurological Sciences

Vol. 381

Páginas: 298-304

ISSN: 0022-510X

Editora: Elsevier

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 1 Citação

Outras Informações

ID Authenticus: P-00N-0Q3

DOI: 10.1016/j.jns.2017.09.009

Abstract (EN): Multiple sclerosis (MS) is an inflammatory disease that may also be associated with vascular dysfunction. One master component of vascular regulation is cerebral autoregulation (CA). We aimed to investigate the integrity of CA in MS patients and study its relationship with autonomic dysfunction (AD), magnetic-resonance-imaging (MRI) lesion load and hemodynamic parameters. We enrolled 20 relapsing-remitting MS and 20 healthy subjects. CA was assessed by transfer function analysis parameters (coherence, gain and phase), as obtained in the very low, low and high-frequency domains (VLF, LF, HF, respectively). We evaluated the autonomic parameters heart rate variability and spontaneous baroreflex sensitivity (BRS). There were no significant differences in CA parameters between MS and controls (p > 0.05). Lesion load was not correlated with any CA parameter. LF gain was positively correlated with BRS in both groups (MS: p = 0.017; controls: p = 0.025). Brainstem lesion load in MS was associated with higher systolic blood pressure (SBP; p = 0.009). Our findings suggest that CA is preserved in our MS cohort. On the other hand, AD in MS patients with brainstem lesions could contribute to the increase of supine SBP. Whether this systemic deregulation could contribute to disease burden remains to be investigated.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7