Age-Related Effects of Dexamethasone Administration in Adrenal Zona Reticularis

• Tipo: Artigo em Revista Científica Internacional
• Data: 2006

Autores

Almeida, Henrique (Autor) FMUP; Matos, Liliana (Autor) FCNAUP; Jorge Ferreira (Autor) Outra; Delminda Neves (Autor) FMUP

Revista

A Revista está pendente de validação pelos Serviços Administrativos.

Título: UNDERSTANDING AND MODULATING AGING

Vol. 22

Páginas: 354-360

Indexação

ISI Web of Knowledge - 6 Citações

ISI Web of Science

Scopus - 7 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina clínica

CORDIS: Ciências Naturais > Ciências biológicas > Biologia > Biologia celular ; Ciências da Saúde > Ciências Médicas > Medicina > Endocrinologia

Outras Informações

ID Authenticus: P-004-QVV

DOI: 10.1196/annals.1354.050

Abstract (EN): Suppression of adrenocorticotropic hormone results in reduced adrenal steroid output, adrenocortical cell atrophy, and apoptosis in young rats. To verify such effects during aging, dexamethasone was injected into rats for 3 days at five different ages; at day 4, adrenals and blood were collected for morphologic and corticosterone assay. Adrenal structure was similar at all ages, but in dexamethasone-injected animals there were ultrastructural features of apoptosis and a higher percentage of TUNEL and caspase-3-labeled nuclei and cytoplasm; their corticosterone decreased significantly. In both groups, there was age-related decrease in the percentage of apoptotic cells, significant only in dexamethasone-injected rats. The data suggest that aged adrenocortical cells are less susceptible to the lack of adrenocorticotropic hormone (ACTH), possibly as a result of their decreased functional ability.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7