Response of jejunal Na+,K+-ATPase to 5-hydroxytryptamine in young and adult rats: Effect of fasting and refeeding

• Tipo: Artigo em Revista Científica Internacional
• Data: 2000

Autores

Lucas Teixeira, V (Autor) Outra; Maria Paula Serrão (Autor) FMUP; soares-da-silva, p (Autor) FMUP

Revista

Título: Acta Physiologica Scandinavica

Vol. 169

Páginas: 167-172

ISSN: 0001-6772

Editora: Blackwell

Indexação

ISI Web of Knowledge - 4 Citações

Scopus - 4 Citações

Outras Informações

ID Authenticus: P-000-ZRN

DOI: 10.1046/j.1365-201x.2000.00721.x

Abstract (EN): The present study is aimed to evaluate the effects of 5-hydroxytryptamine (5-HT) upon jejunal Na+, K+-ATPase in young (20-day-old) and adult (60-day-old) rats, and determine the effect of food intake on the response of the sodium pump to the amine. Basal Na+, K+-ATPase activity in jejunal epithelial cells from young rats was twice that in adult animals and responded to 5-HT with stimulation. In adult rats, fasting reduced by 25% basal jejunal Na+,K+-ATPase activity, whereas in young rats, no such change was observed. The sensitivity of jejunal Na+,K+-ATPase to 5-HT in young fasted rats was similar to that observed in fed animals. The effect of refeeding in young rats was a 2-fold increase in jejunal Na+, K+-ATPase activity, this being accompanied by insensitivity to 5-HT. In adult rats, refeeding was accompanied by an increase in jejunal Na+,K+-ATPase activity. It is concluded that the stimulatory effect of 5-HT upon jejunal Na+,K+-ATPase activity is a phenomenon dependent on both age and type of diet. In young rats, it is the food intake that plays an important role in development of insensitivity of Na+,K+-ATPase to stimulation by 5-HT, while in adult animals fasting or fasting followed by refeeding does not play a major role in regulating its sensitivity to the amine.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6