Altered dopaminergic transmission in the anorexic anx/anx mouse striatum

• Tipo: Artigo em Revista Científica Internacional
• Data: 2001

Autores

Johansen, JE (Autor) Outra; Teixeira, VL (Autor) Outra; Johansson, C (Autor) Outra; Maria Paula Serrão (Autor) FMUP; Berggren, PO (Autor) Outra; soares-da-silva, p (Autor) FMUP; Schalling, M (Autor) Outra; Bertorello, AM (Autor) Outra

Revista

Título: NeuroReport

Vol. 12

Páginas: 2737-2741

ISSN: 0959-4965

Editora: Wolters Kluwer Health

Indexação

ISI Web of Knowledge - 11 Citações

Scopus - 11 Citações

Outras Informações

ID Authenticus: P-000-TJE

DOI: 10.1097/00001756-200108280-00029

Abstract (EN): We demonstrate abnormal dopaminergic neurotransmission in anorexic mice, homozygous for a recessive mutation (anx) causing starvation and motor disturbances. Isolated neurons from anx/anx striatum displayed a markedly increased activity of the Na+,K+-ATPase compared with normal littermates. Dopamine down-regulates Na+,K+-ATPase activity in striatal medium spiny neurons in rat, mouse and guinea pig. However, addition of dopamine in vitro failed to suppress the increased activity in anx/anx striatal neurons. Striatal dopamine and its metabolites, but not norepinephrine, were slightly but significantly lower in anx/anx mice than in normal littermates. We suggest that abnormal dopaminergic transmission may contribute to the anx phenotype. NeuroReport 12:2737-2741 (C) 2001 Lippincott Williams & Wilkins.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5