cTnI, BNP and CRP profiling after seizures in patients with drug-resistant epilepsy

• Tipo: Artigo em Revista Científica Internacional
• Data: 2020

Autores

Faria, MT (Autor) Outra; Rego, R (Autor) Outra; Rocha, H (Autor) Outra; Sa, F (Autor) Outra; Farinha, R (Autor) Outra; Oliveira, A (Autor) Outra; Barata, P (Autor) Outra; Alves, D (Autor) Outra; Pereira, Jorge (Autor) Outra; Rocha Goncalves, F (Autor) Outra; Hernani Goncalves (Autor) FMUP; Martins, E (Autor) FMUP

Revista

Título: Seizure : the journal of the British Epilepsy Association

Vol. 80

Páginas: 100-108

ISSN: 1059-1311

Editora: Elsevier

Indexação

ISI Web of Knowledge - 3 Citações

Scopus - 3 Citações

Outras Informações

ID Authenticus: P-00S-AJA

DOI: 10.1016/j.seizure.2020.06.003

Abstract (EN): Purpose: To profile serum levels of high sensitivity Troponin I (hs-cTnI), B-Type Natriuretic Peptide (BNP), and high sensitivity C Reactive Protein (hs-CRP), after epileptic seizures in patients with focal drug-resistant epilepsy, relating the results to the revised SUDEP-7 inventory. Methods: We prospectively evaluated patients admitted to our Epilepsy Monitoring Unit. hs-cTnI, BNP, and hs-CRP were measured at admission and after the first seizure. The revised SUDEP-7 Risk Inventory was calculated. The statistical significance level was set at 0.05. Results: Fifty-eight patients were included (53.4 % female). The index seizure was a focal to bilateral tonic-clonic seizure (FBTCS) in 25.9 % of the patients, and 17.5 % had post-ictal generalized EEG suppression (PGES). After the seizure, 25.9 % had a significant (above 50 %) increase in hs-cTnI, 23.3 % in BNP, and 4.3 % in hs-CRP. About 40 % had cardiovascular risk factors (CRF), without known cardiac disease. The elevation of one biomarker did not compel the elevation of another. hs-cTnI increase was associated with FBTCS, PGES, longer seizures, maximal ictal heart rate, and HR change. Increases in BNP were associated with CRF. hs-CRP increase was associated with PGES. We found no significant association between SUDEP-7 and any biomarker increase. Significance: Several patients had increases in biomarkers of myocardial necrosis/dysfunction after seizures, without significant association with the SUDEP-7 inventory. Different patterns of biomarkers' elevations point to multifactorial pathophysiologies hypothetically associated with incipient myocardial lesions. A larger cohort with follow-up data could help to clarify the clinical relevance of these findings.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9