EFFECTS OF TRAINING AND AN ANABOLIC-STEROID ON MURINE RED SKELETAL-MUSCLE - A STEREOLOGICAL ANALYSIS

• Tipo: Artigo em Revista Científica Internacional
• Data: 1991

Autores

soares, jmc (Autor) Outra; duarte, jar (Autor) FADEUP

Revista

Título: Acta Anatomica

Vol. 142

Páginas: 183-187

ISSN: 0001-5180

Editora: S. Karger AG

Indexação

ISI Web of Knowledge - 15 Citações

Scopus - 19 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-001-QDD

Abstract (EN): The purpose of this study was the evaluation of changes induced by training (swimming 1 h/day, 5 days/week, 6 weeks) and an anabolic hormone (nandrolone decanoate, intramuscular injections of 15 mg . kg-1 per week) on fiber size, capillarization and mitochondrial fraction of murine soleus muscle. The animals (n = 32) were divided into 4 groups: a control group (C), that received the arachis oil carrier; a steroid group (S), that received the hormone; a training group (T), and a group that was submitted to training and to the administration of hormone (S + T). The soleus muscle was selected for quantitative light- and electron-microscopic evaluation. The muscle fiber size was increased in group T and decreased in groups S and S + T. The axial length of capillaries per unit volume of muscle decreased significantly in groups S and T. The number of capillaries per number of fibers showed a significant decrease in groups S and S + T and an increase in group T. The mitochondrial content decreased in group S, which suggested that anabolic steroids can be harmful for these organelles. This hypothesis was confirmed by histological evaluation at the electron-microscopic level. Many swollen and disrupted mitochondria were found in groups S and S + T. The results suggest that administration of nandrolone decanoate may have some deleterious effects on the muscle respiratory system (capillaries and mitochondria).

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5