The Charles Bonnet Syndrome in Patients With Neovascular Age-Related Macular Degeneration: Association With Proton Pump Inhibitors

• Tipo: Artigo em Revista Científica Internacional
• Data: 2017

Autores

Leandro, JE (Autor) Outra; Beato, J (Autor) FMUP; Pedrosa, AC (Autor) Outra; Pinheiro Costa, J (Autor) Outra; Manuel Falcão (Autor) FMUP; Falcão-Reis F (Autor) FMUP; Ângela Carneiro (Autor) FMUP

Revista

Título: Investigative ophthalmology & visual science

Vol. 58

Páginas: 4138-4142

ISSN: 0146-0404

Indexação

ISI Web of Knowledge - 9 Citações

Scopus - 10 Citações

Outras Informações

ID Authenticus: P-00M-XRV

DOI: 10.1167/iovs.16-21270

Abstract (EN): PURPOSE. We investigate the prevalence of the Charles Bonnet syndrome (CBS) in patients with neovascular age-related macular degeneration (AMD) and analyze the role of oral proton pump inhibitors (PPI.$) and other potential risk factors. METIRMS. A total of 510 consecutive patients with neovascular-AMD followed at a single tertiary center in Portugal were screened for CBS. Using a structured questionnaire, psychiatrically healthy individuals were interviewed systematically and divided into a CBS group and a non-CBS group. Demographic data, current medication, and ocular risk factors were collected and compared between the two groups. RESULTS. A total of 500 patients met the inclusion criteria and 471 with complete data were included in the final analysis. The prevalence of CBS was 9.0% (45/500). Using a binary logistic regression model, correlations were found between older age (P = 0.002), FPI intake (P 0.022), poor visual acuity (p = 0.004), and development of CBS. PPIs doubled the risk of CBS front 7% (20/304) to 15% (25/167), with an odds ratio of 2.154. The increased risk for visual hallucinations caused by PPis was independent of age (P = 0.598) and visual acuity (P = 0.739) CONCLUSIONS. The prevalence of CBS in neovascularAMD patients is high and mainly affects older individuals with poor visual acuity. PPIs seem to increase the risk of development of hallucinations independently of the degree of visual loss.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5