TRPV1 (vanilloid receptor) in the urinary tract: expression, function and clinical applications

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2006

Autores

António Avelino Silva (Autor) FMUP; Francisco Cruz (Autor) FMUP

Revista

Título: Naunyn-Schmiedeberg's Archives of Pharmacology

Vol. 373

Páginas: 287-299

ISSN: 0028-1298

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 140 Citações

Scopus - 157 Citações

Outras Informações

ID Authenticus: P-004-JZM

DOI: 10.1007/s00210-006-0073-2

Abstract (EN): The transient receptor potential vanilloid subfamily 1 (TRPV1) is an ion channel activated by capsaicin, heat, protons and endogenous ligands such as anandamide. It is largely expressed in the urinary tract of mammals. Structures in which the receptor expression is firmly established include sensory fibers and urothelial cells, although the presence of TRPV1 in other cell types has been reported. As in other systems, pain perception was the first role attributed to TRPV1 in the urinary tract. However, it is now increasingly clear that TRPV1 also regulates the frequency of bladder reflex contractions, either through direct excitation of sensory fibers or through urothelial-sensory fiber cross talk involving the release of neuromediators from the epithelial cells. In addition, the recent identification of the receptor in urothelial and prostatic cancer cells raise the exciting hypothesis that TRPV1 is involved in cell differentiation. Desensitization of the receptor by capsaicin and resiniferatoxin has been investigated for therapeutic purposes. For the moment, lower urinary tract dysfunctions in which some benefit was obtained include painful bladder syndrome and overactive bladder of neurogenic and non-neurogenic origin. However, desensitization may become obsolete when non-toxic, potent TRPV1 antagonists become available.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 13