TET enzymes in neurophysiology and brain function

• Tipo: Artigo em Revista Científica Internacional
• Data: 2019

Autores

Antunes, C (Autor) Outra; Sousa, N (Autor) Outra; Pinto, L (Autor) Outra; Joana Marques, CJ (Autor) FMUP

Revista

Título: Neuroscience and Biobehavioral Reviews

Vol. 102

Páginas: 337-344

ISSN: 0149-7634

Editora: Elsevier

Indexação

ISI Web of Knowledge - 31 Citações

Scopus - 35 Citações

Outras Informações

ID Authenticus: P-00Q-M3J

DOI: 10.1016/j.neubiorev.2019.05.006

Abstract (EN): The dynamic nature of epigenetic DNA modifications is crucial for regulating gene expression in an experience dependent manner and, thus, a potential mediator of neuronal plasticity and behavior. The discovery of the involvement of 5-hydroxymethylcytosine (5hmC) and Ten Eleven Translocation (TET) family of enzymes in the demethylation pathway uncovered a potential link between neuronal TET protein function and cognitive processes. In this review, we provide an overview on how profile of 5hmC and TET enzymes are powerful mechanisms to explain neuronal plasticity and long-term behaviors, such as cognition. More specifically, we discuss how the current knowledge integrates the function of each TET enzyme in neurophysiology and brain function.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8