Decreased renal function in overweight and obese prepubertal children

• Tipo: Artigo em Revista Científica Internacional
• Data: 2015

Autores

Correia Costa, L (Autor) Outra; Alberto Caldas Afonso (Autor) FMUP; Schaefer, F (Autor) Outra; guimaraes, jt (Autor) FMUP; Bustorff, M (Autor) Outra; Antonio Guerra (Autor) FMUP; Barros H (Autor) FMUP; Azevedo A (Autor) FMUP

Revista

Título: Pediatric Research

Vol. 78

Páginas: 436-444

ISSN: 0031-3998

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 34 Citações

Scopus - 38 Citações

Outras Informações

ID Authenticus: P-00G-PMB

DOI: 10.1038/pr.2015.130

Abstract (EN): BACKGROUND: Obesity is a potentially modifiable risk factor for the development and progression of kidney disease, both in adults and children. We aim to study the association of obesity and renal function in children, by comparing estimated glomerular filtration rate (eGFR) in nonoverweight and overweight/obese children. Secondarily, we aim to evaluate the accuracy of equations on eGFR estimation when compared to 24-h urinary creatinine clearance (CrCI). METHODS: Cross-sectional study of 313 children aged 8-9 y, followed in the birth cohort Generation XXI (Portugal). Creatinine and cystatin C, GFR estimated by several formulas and CrCI were compared in 163 nonoverweight and 150 overweight/obese, according to World Health Organization growth reference. RESULTS: Overweight/obese children had significantly lower eGFR, estimated by all methods, except for CrCI and revised Schwartz formula. Despite all children having renal function in the normal range, eGFR decreased significantly with BMI z-score (differences ranging from -4.3 to -1.1 ml/min/1.73 m(2) per standard deviation of BMI). The Zappitelli combined formula presented the closest performance to CrCI, with higher correlation coefficients and higher accuracy values. CONCLUSION: Young prepubertal children with overweight/obesity already present significantly lower GFR estimations that likely represent some degree of renal impairment associated with the complex deleterious effects of adiposity.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9