Anthocyanins as Antidiabetic Agents-In Vitro and In Silico Approaches of Preventive and Therapeutic Effects

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2020

Autores

Oliveira, H (Autor) FCUP; Fernandes, A (Autor) Outra; Natercia F Bras (Autor) FCUP; Nuno Mateus (Autor) FCUP; Victor de Freitas (Autor) FCUP; Iva Fernandes (Autor) FCUP

Revista

Título: Molecules

Vol. 57

Página Final: 3813

ISSN: 1420-3049

Editora: MDPI

Indexação

ISI Web of Knowledge - 60 Citações

Scopus - 67 Citações

Outras Informações

ID Authenticus: P-00S-MMR

DOI: 10.3390/molecules25173813

Abstract (EN): Many efforts have been made in the past two decades into the search for novel natural and less-toxic anti-diabetic agents. Some clinical trials have assigned this ability to anthocyanins, although different factors like the food source, the amount ingested, the matrix effect and the time of consumption (before or after a meal) seem to result in contradictory conclusions. The possible mechanisms involved in these preventive or therapeutic effects will be discussed-giving emphasis to the latest in vitro and in silico approaches. Therapeutic strategies to counteract metabolic alterations related to hyperglycemia and Type 2 Diabetes Mellitus (T2DM) may include: (a) Inhibition of carbohydrate-metabolizing enzymes; (b) reduction of glucose transporters expression or activity; (c) inhibition of glycogenolysis and (d) modulation of gut microbiota by anthocyanin breakdown products. These strategies may be achieved through administration of individual anthocyanins or by functional foods containing complexes of anthocyanin:carbohydrate:protein.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 30