The role of the human leukocyte antigen system in retinopathy of prematurity: a pilot study

• Tipo: Artigo em Revista Científica Internacional
• Data: 2013

Autores

Filipa Flor-de-Lima (Autor) FMUP; Rocha, G (Autor) Outra; Proenca, E (Autor) Outra; Tafulo, S (Autor) Outra; Freitas, F (Autor) Outra; Guimarães H (Autor) FMUP

Revista

Título: Acta Paediatrica

Vol. 102

Páginas: 1150-1153

ISSN: 0803-5253

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-008-GNB

DOI: 10.1111/apa.12410

Abstract (EN): AimTo assess the association between the human leukocyte antigen system and retinopathy of prematurity. MethodsNeonates of <32weeks of gestational age, born at two level III neonatal intensive care units from January 2000 to December 2001 and from January 2006 to June 2009, were included in the study. Demographic and clinical data were recorded, and retinopathy was classified according to the International Classification. Epithelial cells were collected from the oral cavity and the HLA were studied using the PCR/SSO method. Univariate and multivariate analyses were performed using SPSS (R) v.18. ResultsWe evaluated 156 neonates, including 82 (52.6%) males. Median gestational age was 29 (23-31) weeks, and median birth weight was 1030 (525-1935) grams. Seventy (44.9%) of the neonates developed retinopathy. Alleles HLA-B*38, HLA-Cw*12, HLA-DRB1*09, HLA-DRB1*14 (univariate analysis) and HLA-A*68 and HLA-Cw*12 were associated to retinopathy (multivariate analysis). ConclusionThe results suggest that the HLA system may be associated with the development of retinopathy of prematurity. A large-scale population-based study should be performed to clarify this association.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 4