Cord blood levels of IL-6, IL-8 and IL-10 may be early predictors of bronchopulmonary dysplasia in preterm newborns small for gestational age

• Tipo: Artigo em Revista Científica Internacional
• Data: 2012

Autores

Rocha, G (Autor) Outra; Proenca, E (Autor) Outra; Guedes, A (Autor) Outra; Carvalho, C (Autor) Outra; Areias, A (Autor) Outra; Ramos, JP (Autor) Outra; Rodrigues, T (Autor) FMUP; Guimarães H (Autor) FMUP

Revista

Título: Disease Markers

Vol. 33

Páginas: 51-60

ISSN: 0278-0240

Editora: Hindawi

Indexação

ISI Web of Knowledge - 34 Citações

Scopus - 37 Citações

Outras Informações

ID Authenticus: P-002-G8E

DOI: 10.3233/dma-2012-0903

Abstract (EN): Introduction: Various cytokines have been associated to the occurrence of bronchopulmonary dysplasia (BPD) in preterm neonates. AIM: To establish an association between cord blood cytokines and BPD, so that they could be used, in clinical practice, as early markers of BPD. Material and methods: Preterms less than 30 weeks gestational age, were analysed by ELISA microassay for venous cord blood IL-1 beta, IL-6, IL-8, TNF-alpha and IL-10, and compared between the BPD and non-BPD groups. Results: One hundred and fifty neonates completed the study; 31 (21%) small for gestational age (SGA); 16 were deceased before 28 days of life; 36 developed mild BPD and 20 developed moderate/severe BPD. Elevated cord blood IL-8 was associated with death or moderate/severe BPD. SGA patients with moderate/severe BPD presented higher cord blood values of IL-8, lower IL-6 and IL-10 when compared with SGA without moderate/severe BPD; and higher IL-8 levels when compared with patients without moderate/severe BPD. Conclusion: These results support an association between cord blood IL-8 and moderate/severe BPD, independently of the intra-uterine growth; and the association of cord blood IL-6 and IL-10 and moderate/severe BPD in SGA preterm newborns.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10