Neonatal Alloimmune Neutropenia: Still a Diagnostic and Therapeutical Challenge

• Tipo: Artigo em Revista Científica Internacional
• Data: 2012

Autores

Agueda, S (Autor) Outra; Rocha, G (Autor) Outra; Ferreira, F (Autor) Outra; Vitor, B (Autor) Outra; Lima, M (Autor) ICBAS; Guimarães H (Autor) FMUP

Revista

Título: Journal of Pediatric Hematology/Oncology

Vol. 34

Páginas: 497-499

ISSN: 1077-4114

Editora: Wolters Kluwer Health

Indexação

ISI Web of Knowledge - 5 Citações

Scopus - 9 Citações

Outras Informações

ID Authenticus: P-002-54V

DOI: 10.1097/mph.0b013e318266c3b5

Abstract (EN): Objective: To describe a case of neonatal alloimmune neutropenia (NAN), a very rare disease of the newborn and the first ever reported in our neonatal intensive care unit, with emphasis in its management and outcome. Description: We report a case of NAN due to anti-human neutrophil antigen-1b alloimmunization in a 29-week preterm admitted to our neonatal intensive care unit. In this case, the neutropenia was severe and persisted for almost 2 months. There was a good response to the administration of intravenous immunoglobulin. Comments: NAN is caused by maternal production of neutrophilspecific alloantibodies in response to antigens from paternal heritage present on the newborn neutrophiles. The course of the disease is usually mild and self-limiting. The optimal therapy is yet a debate, with some authors finding the use of intravenous immunoglobulin effective, prophylactic antibiotic therapy or recombinant human granulocyte colony-stimulating factor.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 3