Polysaccharide-based delivery systems for curcumin and turmeric powder encapsulation using a spray-drying process

• Tipo: Artigo em Revista Científica Internacional
• Data: 2020

Autores

Goelo, V (Autor) Outra; Chaumun, M (Autor) Outra; Goncalves, A (Autor) Outra; Berta Nogueiro Estevinho (Autor) FEUP; Fernando Rocha (Autor) FEUP

Revista

Título: Powder Technology

Vol. 370

Páginas: 137-146

ISSN: 0032-5910

Editora: Elsevier

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 6 Citações

Classificação Científica

CORDIS: Ciências Tecnológicas

FOS: Ciências da engenharia e tecnologias

Projetos Associados

MicroDelivery - Desenvolvimento de sistemas funcionais de libertação controlada por microencapsulação de compostos ativos e naturais, com interesse terapêutico, nutricional e tecnológico

Outras Informações

ID Authenticus: P-00S-5X4

DOI: 10.1016/j.powtec.2020.05.016

Abstract (EN): Curcumin is a hydrophobic polyphenol with a large spectrum of pharmacological functions, such as anti-inflammatory, anticarcinogenic and antioxidant, among others. Due to its chemical instability, the incorporation of curcumin into carrier-based delivery systems has been proposed to improve its stabilization and bioavailability in the human body. The present work suggests the spray-drying technique for the encapsulation of curcumin and turmeric powder (with the active compound curcumin) using the polysaccharides pectin, maltodextrin, inulin and xanthan as encapsulating agents. A product yield between 7.52 and 60.60% was registered for all the micro-particles produced: empty, loaded with turmeric powder and loaded with curcumin. Microparticles with a spherical form, rough surface (pectin, maltodextrin and xanthan microparticles) and smooth surface (inulin microparticles) were produced. The fastest core compound release from curcumin- and turmeric powder-loaded microparticles was registered with inulin and maltodextrin, respectively. The most appropriate kinetic model to describe the registered release profiles is the Weibull model.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10