Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development

• Tipo: Artigo em Revista Científica Internacional
• Data: 2007

Autores

Benninger, Y (Autor) Outra; Thurnherr, T (Autor) Outra; Pereira, JA (Autor) Outra; Krause, S (Autor) Outra; Wu, X (Autor) Outra; Chrostek Grashoff, A (Autor) Outra; Herzog, D (Autor) Outra; Nave, KA (Autor) Outra; Franklin, RJM (Autor) Outra; Meijer, D (Autor) Outra; Brakebusch, C (Autor) Outra; Suter, U (Autor) Outra; Relvas, JB (Autor) Outra

Revista

Título: Journal of Cell Biology

Vol. 177

Páginas: 1051-1061

ISSN: 0021-9525

Editora: Rockefeller University Press

Indexação

ISI Web of Knowledge - 119 Citações

Scopus - 143 Citações

Outras Informações

ID Authenticus: P-005-708

DOI: 10.1083/jcb.200610108

Abstract (EN): During peripheral nervous system ( PNS) myelination, Schwann cells must interpret extracellular cues to sense their environment and regulate their intrinsic developmental program accordingly. The pathways and mechanisms involved in this process are only partially understood. We use tissue-specific conditional gene targeting to show that members of the Rho GTPases, cdc42 and rac1, have different and essential roles in axon sorting by Schwann cells. Our results indicate that although cdc42 is required for normal Schwann cell proliferation, rac1 regulates Schwann cell process extension and stabilization, allowing efficient radial sorting of axon bundles.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 11