Molecular Imprinting of Complex Matrices at Localized Surface Plasmon Resonance Biosensors for Screening of Global Interactions of Polyphenols and Proteins

• Tipo: Artigo em Revista Científica Internacional
• Data: 2016

Autores

Lara Guerreiro, JRL (Autor) Outra; Bochenkov, VE (Autor) Outra; Runager, K (Autor) Outra; Aslan, H (Autor) Outra; Dong, MD (Autor) Outra; Enghild, JJ (Autor) Outra; Victor de Freitas (Autor) FCUP; Ferreira Sales, MGF (Autor) Outra; Sutherland, DS (Autor) Outra

Revista

Título: ACS Sensors

Vol. 1

Páginas: 258-264

Editora: American Chemical Society

Indexação

ISI Web of Knowledge - 29 Citações

Scopus - 33 Citações

Outras Informações

ID Authenticus: P-00M-5C8

DOI: 10.1021/acssensors.5b00054

Abstract (EN): Molecular imprinting polymers (MIP) have been applied to capture and stabilize complex protein matrices at plasmonic sensor surfaces. Ultrathin MIP layers at the surface of gold nanodisks enable the label free quantification of global interactions of polyphenols with protein mixtures. Separate polyphenols (catechin, procyanidin B3- catechin dimer, and PGG-pentagalloyl glucose) give specific and different binding levels to the MIP supported saliva plasmonic sensor. The demonstrated biosensor has application to study bioavailability of polyphenols or evaluation of local retention of small drug molecules.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7