Comparison of the Nancy Index With Continuous Geboes Score: Histological Remission and Response in Ulcerative Colitis

• Tipo: Artigo em Revista Científica Internacional
• Data: 2020

Autores

Magro F (Autor) FMUP; Lopes, J (Autor) Outra; Borralho, P (Autor) Outra; Dias C (Autor) FMUP; Afonso, J (Autor) Outra; Ministro, P (Autor) Outra; Santiago, M (Autor) Outra; Geboes, K (Autor) Outra; Carneiro F (Autor) FMUP; Lopes, S (Autor) Outra; Coelho, R (Autor) Outra; Cotter, J (Autor) Outra; de Castro, FD (Autor) Outra; de Sousa, HT (Autor) Outra; Salgado, M (Autor) Outra; Andrade, P (Autor) Outra; Vieira, A (Autor) Outra; Figueiredo, P (Autor) Outra; Caldeira, P (Autor) Outra; Sousa, A (Autor) Outra; Duarte, M (Autor) Outra; Ávila, F (Autor) Outra; Silva, J (Autor) Outra; Moleiro, J (Autor) Outra; Mendes, S (Autor) Outra; Giestas, S (Autor) Outra; Sousa, P (Autor) Outra; Gonçalves, R (Autor) Outra; Gonçalves, BM (Autor) Outra; Oliveira, AM (Autor) Outra; Chagas, C (Autor) Outra; Portuguese IBD Study Group [GEDII], (Autor) Outra

Revista

Título: Journal of Crohn's and Colitis

Vol. 14

Páginas: 1021-1025

ISSN: 1873-9946

Editora: Oxford University Press

Indexação

ISI Web of Knowledge - 20 Citações

Scopus - 22 Citações

Outras Informações

ID Authenticus: P-00S-HJY

DOI: 10.1093/ecco-jcc/jjaa010

Abstract (EN): Background and Aims: Evidence has been supporting that histological activity of ulcerative colitis [UC] has relevance for the prediction of clinical outcomes in UC patients, such as clinical relapse. In this study, we aimed to compare two histological indexes-the continuous Geboes score [GS] and the Nancy index [NI] -regarding their definitions of histological remission and response, and to determine the ability of faecal calprotectin [FC] levels to discriminate between these histological statuses according to the NI. Methods: A large cohort of UC patients [N = 422] who were previously enrolled in other studies was analysed. Results: GS and NI were shown to be strongly correlated [correlation coefficient: 0.882, p<0.001], indicating high accordance in the classification of patients as having/not having histological remission and response. FC levels moderately correlated with NI regarding these histological statuses [correlation coefficient: 0.481, p<0.001], moderately predicted the absence of remission defined by NI >0 {area under the curve (AUC) 0.667 (95% confidence interval [CI] 0.609-0.724)}, and were good predictors of the absence of histological response defined by NI >1 (AUC 0.825 [95% CI 0.777-0.872]). The optimal FC cut-offs determined to predict the NI-defined histological remission and response were 91 mu g/g and 106 mu g/g, when maximising the negative predictive value [NPV]. Conclusions: Due to the higher applicability of the NI, this study encourages the systematic use of this histological index to assess histological remission and response in UC patients.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5