Second level screening test for chromosomal abnormalities in the first trimester: The role of ductus venosus

• Tipo: Artigo em Livro de Atas de Conferência Internacional
• Data: 2000

Autores

matias, a (Autor) FMUP; Montenegro, N (Autor) Outra; Areias JC (Autor) FMUP; Nicolaides, K (Autor) Outra

Ata de Conferência Internacional

Título: FETUS AS A PATIENT

Páginas: 35-41

16th International Congress on The Fetus as a Patient

FIUGGI, ITALY, APR 01-05, 2000

Indexação

ISI Web of Knowledge - 0 Citações

Outras Informações

ID Authenticus: P-001-1GC

Abstract (EN): In this study we investigated the possible contribution of Doppler assessment of ductus venosus (DV) blood flow in screening for chromosomal abnormalities at 11-14 weeks of gestation. DV blood flow waveforms were obtained immediately before fetal karyotyping in 515 consecutive singleton pregnancies at 11-14 weeks. In all cases screening for chromosomal defects was pet-formed by a combination of maternal age and fetal nuchal translucency thickness. There were 69 chromosomal defects (43 trisomies 21; 12 trisomies 18; seven trisomies 13, four Turner syndromes and three triploidies). In 62/69 (89.8%) cases there was reverse or absent flow during atrial contraction. Abnormal ductal flow was also observed in 17/446 (3.8%) chromosomally normal fetuses, seven of which had cardiac defects. We suggest that assessment of DV blood flow in pregnancies considered to be at high-risk for chromosomal defects may result in a major reduction in the need for invasive testing with only a small decrease in sensitivity.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7