The mammalian nonsense-mediated mRNA decay pathway: To decay or not to decay! Which players make the decision?

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2009

Autores

Silva, AL (Autor) Outra; Romao, L (Autor) Outra

Revista

Título: FEBS Letters

Vol. 583

Páginas: 499-505

ISSN: 0014-5793

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 94 Citações

Scopus - 82 Citações

Outras Informações

ID Authenticus: P-003-N7Y

DOI: 10.1016/j.febslet.2008.12.058

Abstract (EN): Nonsense-mediated mRNA decay (NMD) degrades mRNAs carrying premature translation termination codons (PTCs). Although the core process and several NMD effectors are conserved among species, the involvement of a splicing-dependent signal seems to be specific for mammalian PTC definition. Still, recent data shed new light on physical parameters and mechanistic pathways involved in NMD. Here, we examine these findings, updating the roles for potential NMD players, such as the exon junction complex and the cytoplasmic poly(A)-binding protein 1 - the former acting as enhancer rather than an essential factor and the latter functioning as NMD repressor.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7