The emergent phenomenon of aspirin resistance: insights from genetic association studies

• Tipo: Artigo em Revista Científica Internacional
• Data: 2020

Autores

Ferreira, M (Autor) Outra; Freitas Silva, M (Autor) FMUP; Assis, J (Autor) Outra; Pinto, R (Autor) Outra; José Pedro Nunes (Autor) FMUP; Rui Medeiros (Autor) ICBAS

Revista

Título: Pharmacogenomics

Vol. 21

Páginas: 125-140

ISSN: 1462-2416

Editora: ASHLEY PUBLICATIONS LTD

Indexação

ISI Web of Knowledge - 27 Citações

Scopus - 34 Citações

Outras Informações

ID Authenticus: P-00R-MAD

DOI: 10.2217/pgs-2019-0133

Abstract (EN): Despite the clinical benefits of aspirin, the interindividual variation in response to this antiplatelet drug is considerable. The manifestation of aspirin resistance (AR) is frequently observed, although this complex process remains poorly understood. While AR etiology is likely to be multifactorial, genetic factors appear to be preponderant. According to several genetic association studies, both genome-wide and candidate gene studies, numerous SNPs in cyclooxygenase, thromboxane and platelet receptors-related genes have been identified as capable of negatively affecting aspirin action. Thus, it is essential to understand the clinical relevance of AR-related SNPs as potential predictive and prognostic biomarkers as they may be essential to defining the AR phenotype.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 16