The opportunistic effect of exosomes on Non-Hodgkin Lymphoma microenvironment modulation

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2019

Autores

Fernandes, M (Autor) Outra; Teixeira, AL (Autor) Outra; Rui Medeiros (Autor) ICBAS

Revista

Título: Critical Reviews in Oncology/Hematology

Vol. 144

ISSN: 1040-8428

Editora: Elsevier

Indexação

ISI Web of Knowledge - 9 Citações

Scopus - 11 Citações

Outras Informações

ID Authenticus: P-00R-BWF

DOI: 10.1016/j.critrevonc.2019.102825

Abstract (EN): There has been a shift in the paradigm of Non-Hodgkin lymphomas, changing from the classical genetic aberration-based model to a more complex and dynamic model involving tumor microenvironment interactions. In this instance, exosomes have emerged as important mediators in intercellular communication by providing survival and proliferation signals, licensing immune evasion and acquisition of drug resistance. The capability to transfer molecular cargo made exosomes a focus of research to understand cancer pathogenesis and its progression pathways. Several studies identified exosomes transporting tumor-released components in peripheral blood and focused on understanding their clinical relevance in the diagnosis, prognostic and in monitoring cancer progression. Moreover, due to their biophysical properties and physiological function, exosomes have drawn attention as potential therapeutic target and drug delivery vehicles. This review will discuss the function of exosomes in Non-Hodgkin lymphomagenesis, highlight their potential as diagnosis and prognosis biomarkers, and as new therapeutic opportunities in lymphoma management.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 12